乙肝病毒感染对肝癌TACE术后复发转移的影响研究

目的：探讨乙肝病毒（HBV）感染对原发性肝癌患者行TACE术后复发和生存情况的影响。方法：选取本院收治并确诊的原发性肝癌患者78例,其中HBV感染者32例（HBV组）,非感染者46例（NHBV）。两组患者均行TACE术治疗,采用Kaplan-Meier方法计算术后1、2、3年生存率、复发率及中位生存时间。结果：HBV组患者TACE术后的中位生存时间为19个月,术后1、2、3年累积生存率分别为81.25%、59.38%、37.50%,术后1、2、3年累积复发率分别为37.50%、71.88%、93.75%;NHBV组患者TACE术后的中位生存时间为32个月,术后1、2、3年累积生存率分别为86.96%、71.74%、52.17%,术后1、2、3年累积复发率分别为26.09%、52.17%、80.43%,两组患者术后中位生存时间、生存率及复发率比较,差异均具有统计学意义（P〈0.05）。结论：HBV感染是原发性肝癌患者TACE术后复发转移的危险因素之一,积极给予抗HBV感染治疗可有效延长原发性肝癌患者术后生存时间,降低复发率。

Effect of Hepatitis B Virus Infection in Prognosis of Primary Liver Cancer after TACE Therapy

Objective： To discuss the effect of Hepatitis B virus（HBV）infection in prognosis of primary liver cancer after TACE therapy.Method： 78 cases of patients with Hepatocellular carcinoma were selected,and among them, 32 cases patients with HBV patients（HBV group）, 46 cases of patients without infected（NHBV group）. All of the patients were treated by TACE therapy, and its survival rate, recurrence rate and median survival time were calculated by Kaplan-Meier method. Result： For the patients of HBV group, the median survival time was 19 months, and the survival rates of 1, 2, 3 year after operation were 81.25%, 59.38%, 37.50%, the recurrence rate of 1, 2, 3 year after operation 37.50%, 71.88% and 93.75%. For the patients of NHBV group, the median survival time was 32 months, and the survival rates of 1, 2, 3 year after operation were 86.96%, 71.74%, 52.17%,the recurrence rate of 1, 2, 3 year after operation 26.09%, 52.17%, 80.43%.There were statistical significance between the two groups（P0.05）. Conclusion： HBV infection are one of the risk factors of prognosis, positive anti HBV infection therapy can effectively prolong the survival time and reduce the recurrence rate after operation.