年龄与原发性高血压患者血压晨峰的相关性研究

目的：探讨年龄对血压晨峰发生的影响。方法：选取2009年10月-2011年10月在本院查体的320例原发性高血压患者，根据患者的年龄将其分为≥60岁组148例和〈60岁组172例。所有患者均监测24 h动态血压，比较两组血压晨峰发生情况并分析年龄与血压晨峰之间的相关性。结果：≥60岁组的年龄、甘油三酯、舒张压、动态血压参数均明显高于〈60岁组，差异均有统计学意义（P〈0.01或P〈0.05）。≥60岁组高血压患者血压晨峰发生率53.4%明显高于〈60岁组的41.9%，血压晨峰值（33.1±18.1）mm Hg明显高于〈60岁组的（27.1±15.5）mm Hg，差异均有统计学意义（P〈0.01或P〈0.05）。Pearson相关性分析显示，血压晨峰与高血压患者年龄呈显著正相关（r=0.583，P〈0.05）。多元线性逐步回归显示，年龄、空腹血糖、24 h收缩压是引起血压晨峰现象的主要危险因素。结论：年龄与血压晨峰的发生显著相关，因此对于老年高血压患者监测24 h血压具有重要的临床意义。

The Correlation Study between Age and Morning Blood Pressure Surge in Primary Hypertensive Patients

Objective：To investigate the effect of age on morning blood pressure surge.Method：320 primary hypertensive patients from October 2009 to October 2011 in our hospital examination were selected.According to the patient’s age,they were divided into ≥60 years old group（n=148）and〈60 years old group（n=172）.All patients received ambulatory blood pressure monitoring,the situation of morning blood pressure surge was compared between two groups and the association between age and morning blood pressure surge was analyzed.Result：Age,diastolic blood pressure,triglyceride and ambulatory blood pressure parameters of ≥60 years old group were significantly higher than those of〈60 years old group,the differences were statistically significant（P〈0.01 or P〈0.05）.The incidence of morning blood pressure surge in≥60 years old group was 53.4%,it was significantly higher than 41.9%in〈60 years old group, and the morning blood pressure surge in≥60 years old group was（33.1±18.1）mm Hg,it was significantly higher than （27.1±15.5）mm Hg in〈60 years old group,the differences were statistically significant（P〈0.01 or P〈0.05）.Pearson correlation analysis showed,the morning blood pressure surge in patients with hypertension and age had a significant positive correlation（r=0.583,P〈0.05）.Multiple linear stepwise regression showed,age,fasting blood glucose, 24 h systolic blood pressure were the main risk factors of morning blood pressure surge.Conclusion：Age is significantly associated with the occurrence of morning blood pressure surge,24 h blood pressure monitoring in elderly hypertensive patients has important clinical significance.