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| 4-氨基-2-氯-6,7-二甲氧基喹唑啉的合成 | |
| 引用本文： | 张庆珍,玄光善,王立兵. 4-氨基-2-氯-6,7-二甲氧基喹唑啉的合成[J]. 中国医药工业杂志, 2011, 42(7) |
| 作者姓名： | 张庆珍 玄光善 王立兵 |
| 作者单位： | 青岛科技大学药学系,山东青岛,266042 |
| 摘 要： | 香草醛经甲基化、硝化、氧化、酯化、还原、环合、氯化及氨化制得盐酸特拉唑嗪等喹唑啉类药物的中间体4-氨基-2-氯-6,7-二甲氧基喹唑啉,并考察了硝化、氧化过程中反应温度和投料比等因素对反应的影响,确立了最佳工艺条件,总收率约37%。 |
| 关 键 词： | 4-氨基-2-氯-6 7-二甲氧基喹唑啉 抗高血压药 中间体 合成 |
Synthesis of 4-Amino-2-chloro-6,7-dimethoxyquinazoline |
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| ZHANG Qingzhen,XUAN Guangshan,WANG Libing. Synthesis of 4-Amino-2-chloro-6,7-dimethoxyquinazoline[J]. , 2011, 42(7) | |
| Authors: | ZHANG Qingzhen XUAN Guangshan WANG Libing |
| Affiliation: | ZHANG Qingzhen,XUAN Guangshan~*,WANG Libing (Dept.of Pharmacy,Qingdao University of Science and Technology,Qingdao 266042) |
| Abstract: | 4-Amino-2-chloro-6,7-dimethoxyquinazoline,a key intermediate of quinazoline drugs such as terazosin,was synthesized from vanillin by methylation,nitration,oxidation,esterification,reduction,cyclization, chlorination and animation.The effects of reaction temperature and mole ratio of the reactants were investigated in the nitration and oxidation.The overall yield of the target compound was about 37%after improvement of the process. |
| Keywords: | 4-amino-2-chloro-6 7-dimethoxyquinazoline antihypertensive intermediate synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |