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The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats |
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| Authors: | Salvatore Serra Mauro A. M. Carai Giuliana Brunetti Raquel Gomez Samuele Melis Giovanni Vacca Giancarlo Colombo Gian Luigi Gessa |
| Affiliation: | a Neuroscienze S.c.a r.l., via Palabanda 9, I-09123, Cagliari, Italy b “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, S.S. 554, Km. 4.5, I-09042 Monserrato (CA), Italy c Department of Psychobiology, Universidad Complutense, Campus de Somosaguas s/n, 28223 Madrid, Spain d C.N.R. Institute of Neurogenetics and Neuropharmacology, c/o “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, S.S. 554, Km. 4.5, I-09042 Monserrato (CA), Italy |
| Abstract: | The cannabinoid CB1 receptor antagonist, N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide) (SR 141716); 0.3–3 mg/kg, i.p., twice daily for 10 days), prevented the acquisition of alcohol drinking behavior in rats genetically selected for alcohol preference (Sardinian alcohol-preferring (sP) rats), having the free choice between alcohol (10%, v/v) and water. The results suggest that activation of cannabinoid CB1 receptors is essential for the acquisition of alcohol drinking behavior in animals with a genetically determined alcohol preference. |
| Keywords: | Cannabinoid CB1 receptor antagonist Alcohol intake Sardinian alcohol-preferring (sP) rat |
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