肝病患者血清胆固醇与总胆汁酸检测的临床意义

目的：通过联合测定肝病患者血清胆固醇（CHO）与总胆汁酸（TBA）的含量水平，以探讨其临床意义。方法对160例肝病患者按照Child-Pugh肝功能分级法分级后与80例健康者比较血清中CHO与TBA水平。结果肝硬化组和肝癌组血清CHO含量明显低于对照组，而TBA含量明显高于对照组（P〈0.01）。CHO在肝硬化组C级中最低，与A级和B级比较差异有统计学意义（P〈0.05）， A级和B级比较差异无统计学意义（P〉0.05）；TBA在A级、B级和C级各级之间比较差异有统计学意义（P〈0.05），且随着肝功能Child-Pugh分级的增高而增高。结论肝病患者CHO、TBA能敏感反映肝功能及肝硬化的进展情况。

Clinical significance of testing serum cholesterol and total bile acid in levels of the patients with liver disease

Objective To evaluate the clinical significance of serum cholesterol （CHO） and total bile acid （TBA） in patients with liver disease. Methods The serum levels of CHO and TBA were prospectively studied in 160 patients with liver disease and 80 healthy persons. Results Serum CHO level was significantly lower in cases with liver cirrhosis and hepatic carcinoma than that of control group （P〈0.05）, but serum TBA level significantly higher （P〈0.01）. Serum CHO level was the lowest in Child-Pugh C grade and was significantly different between C grade and A grade as well as B grade （P〈0.05）. Serum TBA level was significantly different among A, B and C grade, it increased with the liver function of Child-Pugh grade. Conclusion Serum TBA level can sensitively reflect the degree of liver cirrhosis, the tests of TBA and CHO are helpful to confirming the state of patients.