| 聚α-氰基丙烯酸丁酯载药纳米微粒的研究进展 |
| |
| 引用本文： | 戴蔚荃,周长江,崔黎丽,任宏斌,赵卫权.聚α-氰基丙烯酸丁酯载药纳米微粒的研究进展[J].药学服务与研究,2004,4(1):33-35. |
| |
| 作者姓名： | 戴蔚荃 周长江 崔黎丽 任宏斌 赵卫权 |
| |
| 作者单位： | 第二军医大学药学院无机化学教研室,上海,200433 |
| |
| 摘 要： | 目的：对作为药物载体的聚α-氰基丙烯酸丁酯的研究进展进行综述，就其制备工艺、体外释药和体内分布、毒理学和稳定性等作一介绍。方法：查阅聚α-氰基丙烯酸丁酯作为载药毫微粒的国内外文献。结果：聚α-氰基丙烯酸丁酯作为药物载体具有生物利用度高、释药速率可控、靶向性，能够改变药物体内分布等优点。结论：聚α-氰基丙烯酸丁酯作为药物载体具有广阔的应用前景。
|
| 关 键 词： | 聚α-氰基丙烯酸丁酯 纳米微粒 药物载体 制备工艺 生物利用度 释药速率 |
| 文章编号： | 1671-2838(2004)01-0033-03 |
| 修稿时间： | 2003年7月28日 |
The advance in research on drug-loaded nanoparticle of polybutylcyanoacrylate |
| |
| DAI Wei-Quan,ZHOU Chang-Jiang,CUI Li-Li,REN Hong-Bin,ZHAO Wei-Quan.The advance in research on drug-loaded nanoparticle of polybutylcyanoacrylate[J].Pharmaceutical Care and Research,2004,4(1):33-35. |
| |
| Authors: | DAI Wei-Quan ZHOU Chang-Jiang CUI Li-Li REN Hong-Bin ZHAO Wei-Quan |
| |
| Abstract: | Objective: To review the research of polybutylcyanoacrylate(PBCA) as drug-loaded carrier in recent years, and to introduce the preparation methods, drug releasion in vitro, dispersion in vivo, toxicity and stability of polybutylcyanoacrylate nanoparticle (PBCA-NP). Methods: The related literature at home and abroad was consulted. Results: PBCA as drug-loaded carrier had advantages of high degree of biological utilization, controllable drug release rate, targeting and changing drug distribution in vivo. Conclusion: PBCA as drug-loaded carrier has broad application prospects in the future. |
| |
| Keywords: | polybutylcyanoacrylate nanoparticle drug-loaded carrier |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
