第三代头孢菌素类药物不良反应70例分析

目的：为临床合理应用头孢菌素类药物提供参考。方法：分析2006-2008年临床常规静脉使用头孢呱酮、头孢噻肟、头孢曲松、头孢他啶等4种三代头孢菌素类药物的病例2430份，讨论其不良反应发生情况。结果：发生不良反应70例，发生率为2．88％。过敏反应是三代头孢菌素类药物的主要不良反应，神经系统和血液系统反应较少，不良反应的发生与患者年龄、性别差异无显著关联。结论：临床在应用第三代头孢菌素类药物时，不仅应重视其抗菌效应，还应高度关注其不良反应的发生，正确使用，防止滥用。

The Third-Generation Cephalosporin:an Anillysis of 70 Cases of Adverse Drug Efleets

Objective To provide a reference for the clinical rational application of cephalosporin. Methods Analyzing 2430 cases of 4 kinds of the third-generation cephalosporin such as cefoperazone, cefotaxime, ceftriaxone, ceftazidime and so on intravenously used clinically in the year 2006-2008, to discuss the incidence of adverse reactions. Results Adverse effects occurred in 70 cases, with the rate of 2.88%. Allergic reaction is the major adverse reactions of the third-generation of cephalosporin, with fewer side effects to nervous system and blood system. The occurrence of adverse reactions with the patients in age, gender was no significant difference. Conclusion In the clinical application of the third-generation cephalosporin, not only should pay attention to its anti-bacterial effects, but also highly concerned about the adverse effects of its occurrence, the proper use to prevent abuse.