肝硬化门静脉血栓患者血浆D-二聚体水平及其临床意义

目的探讨肝硬化门静脉血栓（PVT）患者血浆D-二聚体水平及其临床意义。方法在77例肝硬化患者中，PVT形成患者31例，无血栓形成患者46例，依据螺旋cT检查诊断PVT，采用乳胶凝集法检测血浆D-二聚体水平。结果血栓组和无血栓组患者血浆D-二聚体水平分别为1．2±0．5mg/l和0．6±0．4mg／l（P〈0．01）；血栓组伴中重度食管静脉曲张患者血浆D-二聚体水平（1-3±O．5m鲫）显著高于轻度食管静脉曲张患者（0．9±0．5mg/l，P〈0．05）；血栓形成伴消化道出血和死亡患者血浆D-二聚体水平显著高于无出血和生存患者（P〈0．01）。结论肝硬化患者血浆D-二聚体水平升高可能与PVT形成有关，并严重影响预后。

The plasma D-dimer levels and their clinical significance in liver cirrhosis patients with portal vein thrombosis

Objective To investigate the plasma D-dimer levels and their clinical significance in liver cirrhosis(LC) patients with portal vein thrombosis(PVT).Methods 77 patients with LC were selected and 31 had PVT,and 46 had not.The PVT was diagnosed by CT scan and the D-dimer levels were detected.Results The plasma D-dimer levels in patients with PVT were significantly higher than that in without PVT(1.2±0.5 mg/l vs.0.6±0.4mg/l,P<0.01);The plasma D-dimer level in PVT patients with severe esophageal varices group(1.3±0.5mg/l) was higher significantly than that in patients with mild esophageal varices group(0.9±0.5mg/l,P<0.05);The plasma D-dimer level in patients with gastrointestinal bleeding(1.5±0.5mg/l) was higher significantly than that in patients without gastrointestinal bleeding(0.8±0.4mg/l,P<0.01);The plasma D-dimer level in death group(1.318±0.512mg/l)was higher significantly than in survived group(1.0±0.4mg/l,P<0.01).Conclusion Plasma D-dimer level increases in patients with LC and might prompt the PVT formation.