HLA-DR antigens in Chinese-American families |
| |
| Authors: | B. Colombe S. Pask H. Cann R. Payne |
| |
| Affiliation: | 1. From the Immunogenetics and Transplantation Laboratory, University of California Medical Center, San Francisco, USA;2. Department of Medicine, Pediatrics, and Genetics, Stanford University Medical School, Stanford, California, USA |
| |
| Abstract: | ![]()
This paper contains results of a study on HLA-DR antigens in Chinese-American families. DR2, DR4, DRw9, and DRw6Y were the most common DR specificities encountered, and DR1 occurred with the lowest frequency. All recognized DR antigens were observed. The frequency of a blank allele was 6.4–12.8%. Weak serologic reactions with sera primarily of Caucasian origin were not infrequently observed. These findings suggested that ethnic-related antigens were present in this population. Two families showed segregation of a new serologic pattern based on polyspecific sera. The gene frequencies of the BfF allele and the GLO1 allele were low as compared to Caucasians. A method is described for improving the yield of viable B cells from frozen B-lymphocyte preparations. |
| |
| Keywords: | FSD Ficoll-sodium diatrizoate SRBC sheep red blood cell PBS phosphate-buffered saline FCS fetal calf serum FDA fluorescein diacetate AOH Asia-Oceania histocompatibility MHC major histocompatibility complex PBL peripheral blood leukocyte |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
