Abstract: | Abstract: Objective To explore the characteristics of serological indicators and cytokines in patients with different
intestinal diseases and further understand the pathogenesis of different intestinal diseases. Methods Serum specimens were
collected from 89 patients with intestinal diseases who sought medical treatment at the affiliated hospital of Medical College
of Jiaying University from March 2021 to March 2022. Immunological testing was performed on serum cytokines (IL-6, IL-9,
and IL-22), and clinical data of the patients were collected. Results 89 patients were divided into the Intestinal Inflammation
Group (35 cases), the Intestinal Tumor Group (20 cases), the Intestinal Polyposis Group (17 cases), the Intestinal Ulcer Group
(13 cases), and the Intestinal Obstruction Group (4 cases) based on the diagnosis of different intestinal diseases. The alpha
fetoprotein (AFP) was significantly higher in the Intestinal Inflammation Group than that in the other five groups (P<0.01),
and the contents of creatine phosphate kinase (CK) and neutrophils (N) was higher in the Intestinal Inflammation Group;
The content of lactate dehydrogenase (LDH) was the highest in the Intestinal Ulcer Group; The content of eosinophils (E)
in the Intestinal Obstruction Group was the lowest, and there was a significant difference when compared with the Intestinal
Inflammation Group, Intestinal Polyposis Group, and Intestinal Polyposis Group (P<0.05). The contents of IL-6, IL-9, and IL-
22 were the highest in the Intestinal Tumor Group, and the contents of IL-6 and IL-9 were significantly lower in the Intestinal
Ulcer Group than those in the Intestinal Inflammation Group and Intestinal Tumor Group (P<0.05). The correlation analysis
showed there was a medium to high correlation relationship among white blood cell (WBC), N, and monocyte (M) (r=0.933,
0.827, and 0.715, all P<0.01 for all); and there was also a medium to high correlation relationship among TBil, DBil, and IBil
(r=0.851, 0.830, and 0.647, P<0.01 for all). Conclusion Among patients with different intestinal diseases, the proportion
of intestinal inflammation is the highest, followed by intestinal tumors. There were significant differences in AFP, CK, N,
LDH, and E in different intestinal diseases. The contents of IL-6, IL-9, and IL-22 were the highest in patients with intestinal
tumors. There was a medium to high correlation among serum indicators such as WBC, N, and M and among TBil, DBil, and
IBil, which is of great significance for predicting whether a patient has related intestinal diseases and evaluating the disease
progression in the patient, as well as for early diagnosis and correct treatment of intestinal disease. |