Effect of amiloride on arachidonic acid and histamine release from rat mast cells |
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| Authors: | H Linnebjerg H S Hansen B Jensen |
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| Affiliation: | Pharma Biotec Research Center, Royal Danish School of Pharmacy, Copenhagen, Denmark. |
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| Abstract: | ![]()
The effect of a putative Na+/H+ exchange inhibition on histamine and [14C]arachidonic acid ([14C]AA) release has been examined in rat peritoneal mast cells, using either addition of amiloride or removal of extracellular Na+. The cells were stimulated by non-immunological agents, i.e. calcium ionophore A23187, nerve growth factor (NGF), thapsigargin and compound 48/80. On the basis of the results obtained, a possible role for Na+/H+ exchange in rat mast cell secretion is discussed. |
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