A mouse monoclonal antibody detecting a DR-related MT2-like specificity: Serology and biochemistry

A mouse monoclonal antibody (7.3.19.1) was produced which reacts with class II molecules on B cells and monocytes of DR3, DR5, and/or DRw6 positive donors only. Using this moab and two others, three different groups of class II molecules could be identified. Furthermore, a differential precipitation pattern was found which correlates with a DR-related variable expression of the MT2-like polymorphic determinant on the cell surface. Addition of 7.3.19.1 to MLCs did not result in significant inhibition in contrast to the two other moabs tested. Normal CTL activity was found in such a stimulated responder population.