| 刺激单核巨噬细胞对肝实质及非实质细胞脂蛋白代谢的影响 |
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| 引用本文： | 何志刚 蔡海江 等. 刺激单核巨噬细胞对肝实质及非实质细胞脂蛋白代谢的影响[J]. 中国病理生理杂志, 1989, 5(6): 358-362 |
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| 作者姓名： | 何志刚 蔡海江 等 |
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| 作者单位： | 南京医学院病理生理学教研室(何志刚，蔡海江)，南京医学院病理生理学教研室(陈秀红) |
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| 摘 要： | 本研究结果表明酵母多糖对喂正常饲料大鼠肝非实质细胞及实质细胞的^125I-HDL及^125I-LDL代谢影响不大，但可明显增加喂高脂饲料大鼠细胞对^125I-HDL及^125I-LDL的结合、内移及降解，增加胆汁中总胆酸及胆固醇的排泄，明显降低高脂饲料导致的高胆固醇血症。
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| 关 键 词： | 单核巨噬细胞 肝脏 低密度脂蛋白类 高密度脂蛋白类 |
Effects of monocytic macrophage stimulation on lipoprotein metabolism of rat parenchymal and nonparenchymal cells |
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| He Zhi-Gang,et al Pathophysiology Department,Nanjing Medical College,Nanjing. Effects of monocytic macrophage stimulation on lipoprotein metabolism of rat parenchymal and nonparenchymal cells[J]. Chinese Journal of Pathophysiology, 1989, 5(6): 358-362 |
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| Authors: | He Zhi-Gang et al Pathophysiology Department Nanjing Medical College Nanjing |
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| Abstract: | Intravenous injection of zymosan had little effects on binding, uptake and degradation of ~(125)I-HDL and ~(125)I-LDL by rat hepatic parenchymal and nonparenchymal cells isolated from chow-fed rats. But for rats fed high-cholesterol diet, it increased binding, uptake and degradation of ~(125)I-HDL and ~(125)I-LDL as well as the contents of cholic acid and cholesterol in bile and inhibited acumulation of plasma cholesterol. |
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| Keywords: | Monocytes Liver Lipoproteins HDL Lipoproteins LDL |
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