旋覆代赭汤联合穴位注射防治化疗后呕吐

目的:观察旋覆代赭汤口服联合黄芪注射液足三里穴位注射防治化疗所致呕吐(CINV)的临床疗效。方法:将72例接受化疗的恶性肿瘤患者随机分为对照组、治疗组,对照组予盐酸昂丹司琼注射液8 mg/次,2次/d。治疗组在对照组治疗基础上给予旋覆代赭汤口服,1剂/d;联合黄芪注射液足三里穴位注射,4 m L/次,2次/d。观察两组呕吐有效控制率、食量及KPS评分变化、体重变化、血象变化及不良反应发生率。结果:对照组、治疗组急性期呕吐有效控制率分别为72.2%,83.3%,延迟期呕吐有效控制率分别为61.1%,75.0%,治疗组均高于对照组,差异有统计学意义(P0.05);治疗组食量增加,KPS评分增加都高于对照组,差异有统计学意义(P0.05);化疗后两组患者体重变化治疗组小于对照组,比较差异有统计学意义(P0.05);两组治疗后白细胞、血小板、血红蛋白浓度治疗组均高于对照组,且差异均有统计学意义(P0.05);治疗组不良反应发生低于对照组,差异有统计学意义(P0.05)。结论:旋覆代赭汤口服联合黄芪注射液足三里穴位注射防治化疗所致呕吐的疗效确切,能明显改善化疗后患者的身体状况及食量,减少不良反应发生,值得在临床上推广应用。

Effect of Xuanfu Daizhe Tang Combined with Point-injection on Chemotherapy-induced Nausea and Vomiting

Objective: To observe the effect of Xuanfu Daizhe Tang combined with point-injection on chemotherapy-induced nausea and vomiting (CINV). Method: Totally 72 patients with chemotherapy for malignant tumors were randomly divided into control group and treatment group. The patients in control group were intravenously injected with ondansetron hydrochloride injection (8 mg/time, bid). Patients in treatment group also received Xuanfu Daizhe Tang by orally taking on the basis of treatment in control group, 1 dose/d and point-injection with Huangqi injection (4 mL/time, bid). The effective control rate for vomiting, appetite, Karnofsky(KPS) score changes, body weight changes, blood indicator changes and adverse event incidence were observed and compared. Result: The effective control rate for vomiting was 72.2% and 83.3% in acute phase respectively for the control group and treatment group;while in the delayed phase, the effective control rate for vomiting was 61.1% and 75.0% respectively;the effective control rates in treatment group were higher than those in control group in both phases, with statistically significant difference between two groups (P<0.05). The increases in appetite and KPS scores in the treatment group were also higher than those in the control group, with statistically significant difference between two groups (P<0.05). After chemotherapy, the body weight changes in treatment group were lower than those in control group, with statistically significant difference between two groups (P<0.05). After chemotherapy, leukocytes, platelet levels and hemoglobin concentration in the treatment group were higher than those in control group, with statistically significant difference between two groups (P<0.05). The incidence of adverse events in the treatment group was all lower than that in the control group, with statistically significant difference between two groups (P<0.05). Conclusion: Xuanfu Daizhe Tang combined with point-injection of Huangqi injection has clear curative effect in the treatment of CINV. It could improve the physical conditions and appetite of patients, and reduce the incidence of adverse events. Therefore, it is worth to be widely used clinically.