微波消解ICP-MS测定藏族药仁青芒觉中的无机元素

目的:藏族药仁青芒觉中富含矿物质元素,除了人体必需的常量、微量元素外,还含有大量的Hg,Pb和As,本试验将通过微波消解-电感耦合等离子体质谱法(ICP-MS)建立藏族药仁青芒觉中24种无机元素含量的测定方法。方法:样品经微波消解后,以铑、铼为内标,用电感耦合等离子体质谱测定样品中Na,Mg,Al,K,Ca,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,As,Se,Mo,Ag,Cd,Au,Hg,Tl,Pb,Th和U共24种元素的含量。结果:该方法对各元素的检出限为0.003 2~2.419 ng·g-1,除汞外,加样回收率在80.62%~108.2%。结论:建立了快速、灵敏度高、准确的测定为藏族药中仁青芒觉中24种无机元素含量的方法,这为进一步研究藏族药仁青芒觉中各元素形态、药理作用和建立其质量标准奠定了基础。

Determination of Inorganic Elements in Renqing Mangjue by ICP-MS

Objective: There are rich in mineral elements in Tibetan medicine Renqing Mangjue, in which contain a lot of Hg, Pb and As besides the human body essential trace elements and macro elements. So to establish the method for determination 24 inorganic elements in Renqing Mangjue by micrwave digestion-inductively coupled plasma mass spectrometry (ICP-MS). Method: A method was studied for the assay of many inorganic elements such as Cr, Mn, Ni, Co, Cu, Zn and As in Renqing Mangjue by microwave digestion-inductively coupled plasma mass spectrometry with Rh and Re as internal standards. Result: Detection limits for above elements were 0.003 2-2.419 g·g^-1, with the recoveries were 80.62%-108.2% except for Hg. Conclusion: Established a fast, accurate and reliable method for assay of 24 inorganic elements in Renqing Mangjue. Which are foundations for the further research the species of every element in Renqing Mangjue, its pharmacological effects and establish the quality standard of Renqing Mangjue.