胆红素水平与新生儿黄疸发生程度的关系分析

目的分析胆红素水平与新生儿黄疸发生程度的关系,探讨胆红素水平检测的临床应用。方法选择2016年5月至2018年5月黄疸新生儿100例,回归性分析其临床资料。100例患儿均给予经皮胆红素值检测,其中轻度黄疸34例,中重度黄疸66例;有核黄疸14例,无核黄疸86例。比较不同临床特征的黄疸新生儿血清总胆红素、非结合胆红素、门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平,分析患儿经皮总胆红素、非结合胆红素水平与肝功能的相关性。结果中重度黄疸患儿总胆红素、非结合胆红素、ALT、AST水平高于轻度黄疸患儿(P<0.05)。有核黄疸患儿总胆红素、非结合胆红素、ALT、AST水平高于无核黄疸患儿(P<0.05)。黄疸患儿总胆红素和非结合胆红素水平与肝功能呈正相关(P<0.05)。结论经皮胆红素水平越高,肝脏细胞膜损伤越大,黄疸程度越严重,经皮胆红素水平检测有助于诊断与评估新生儿黄疸发生程度。

Relationship analysis between serum bilirubin level and occurrence degree of neonatal jaundice

Objective To andlyze the relationship between percutaneous bilirubin level and the incidence of neonatal jaundice.Methods A total of 100 neonates with jaundice admitted from May 2016 to May 2018 were selected for regression analysis of their clinical data.The percutaneous bilirubin value was tested in 100 children,including 34 cases of mild jaundice and 66 cases of moderate to severe jaundice,nuclear jaundice was 14 cases,seedless jaundice was 86 cases.The levels of total bilirubin,non-binding bilirubin,AST and Alt in newborns with different clinical characteristics were compared,the relastionship between the levels of total bilirubin and non-binding bilirubin and liver function in children were analyzed.Results The levels of total bilirubin,unconjugated bilirubin,ALT and AST in children with moderate and severe jaundice were significantly higher than those in children with mild jaundice(P<0.05);the levels of total bilirubin,unconjugated bilirubin,ALT and AST in children with nuclear jaundice were significantly higher than those in children without nuclear jaundice(P<0.05).There was positive correlation of total bilirubin and unconjugated bilirubin levels with liver function in children with jaundice(P<0.05).Conclusion The percutaneous bilirubin level is higher,the greater the damage to the liver cell membrane,the more severe the degree of jaundice.The detection of percutaneous bilirubin level is helpful to diagnose and evaluate the incidence of neonatal jaundice.