三维可视化技术与公式法测定肝脏肿瘤体积的对比研究

目的比较肿瘤体积计算公式与三维可视化技术测得肿瘤体积的差异性,探讨目前医学研究中广泛应用的公式法还能否满足精准医疗的需求。方法①根据阿基米德原理,通过排水法验证三维重建脏器体积的准确性;②收集来自海军军医大学东方肝胆外科医院的200例肝脏肿瘤病人的薄层CT图像及原始DICOM数据,采用三维可视化技术进行肿瘤体积计算(结果记为V4)。两位外科医生采用传统方法测量肿瘤长径(A)、宽(B)、高(C),用三种公式V=AB^2/2、V=ABC/2和球体公式V=4/3×π×(A/2)~3]计算肿瘤体积,结果分别记为V1、V2、V3(第一位测量者)和V5、V6、V7(第二位测量者)。结果①三维重建的预切除肝脏体积与排水法测定的真实切除体积高度相关(P<0.01)。②不同公式法与三维可视化技术测定的肝脏肿瘤体积在总体上有较大误差(均P<0.05);AB^2/2、ABC/2两种公式与三维可视化结果在男性组、女性组、A≤3 cm组、3 cm10 cm组差异均有统计学意义(均P<0.05);球体公式在3 cm

Comparative study of three-dimensional visualization technology vs.traditional formula for measuring liver tumor volume

Objective To compare the difference between the traditional calculation formula and the three-dimensional(3D)visualization technology for tumor volume,and to prove whether the traditional formula widely used in medical research cannot meet the needs of precision medical treatment.Methods ①According to the Archimedes'principle,the accuracy of 3D reconstruction volume of organ was verified by drainage method;②This study collected thin-slice computed tomography(CT)images and original DICOM data of 200 patients with liver tumors from the Eastern Hepatobiliary Surgery Hospital of Naval Military Medical University.The 3D visualization technology(Shenzhen,Xudong)was used to calculate the tumor volume,and the result was V4.Two surgeons used conventional methods to measure tumor length(A),width(B),and height(C)to calculate the tumor volume by formulaeV=AB 2/2,V=ABC/2,and the spherical formula V=4/3×π×(A/2)3].The results were V1-V3 and V5-V7,respectively.Results ①The predicted excisional liver volume determined by 3D technology was highly correlated with the true volume determined by the drainage method(P<0.01).②The liver tumor volume measured by different traditional formulae was generally smaller than 3D visualization technology(P<0.05).The results for two formulae(AB 2/2 and ABC/2)were different from the 3D visualization results in male group,female group,A≤3 cm group,3 cm10 cm group(P<0.05).The difference between V3,V7(spherical formula)and 3D technology was not statistically significant in 3 cm