| 阿立哌唑和利培酮治疗精神分裂症的比较研究 |
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| 引用本文： | 张静,常丽艳. 阿立哌唑和利培酮治疗精神分裂症的比较研究[J]. 中国民康医学, 2011, 23(22): 2765+2778. DOI: 10.3969/j.issn.1672-0369.2011.22.013 |
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| 作者姓名： | 张静 常丽艳 |
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| 作者单位： | 沈阳市铁西区精神卫生中心,辽宁沈阳,110141 |
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| 摘 要： | 目的:以利培酮为对照,探讨阿立哌唑治疗精神分裂症的疗效和安全性。方法:将90例符合CCMD-3诊断标准的精神分裂症随机分为两组,分别给予阿立哌唑组和利培酮组治疗12周。采用阳性症状和阴性症状量表(PANSS)评定临床疗效,副反应量表(TESS)评定副反应。结果:治疗8周后两组疗效近似(P>0.05);阿立哌唑组和利培酮组的显效率差异无显著性(P>0.05);阿立哌唑组的副反应发生率低于利培酮组,但差异无显著性(P>0.05)。利培酮组锥体外系副反应和内分泌改变的发生均明显高于阿立哌唑组(P<0.05)。结论:阿立哌唑和利培酮对精神分裂症的疗效相当,锥体外系和内分泌改变的副作用较小。
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| 关 键 词： | 阿立哌唑 利培酮 精神分裂症 |
Comparative study of Aripiprazole and Risperidone in the treatment of schizophrenia |
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| ZHANG Jing,CHANG Li-yan. Comparative study of Aripiprazole and Risperidone in the treatment of schizophrenia[J]. medical journal of chinese peoples health, 2011, 23(22): 2765+2778. DOI: 10.3969/j.issn.1672-0369.2011.22.013 |
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| Authors: | ZHANG Jing CHANG Li-yan |
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| Affiliation: | ZHANG Jing,CHANG Li-yan(Tiexi District Mental Helth Center of Shenyang city,Shenyang 110141,China) |
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| Abstract: | Objective:To investigate the clinical efficacy and side effects of Aripiprazole in the treatment of schizophrenia.Methods:90 patients with schizophrenia by CCMD-3 were randomly allocated to two groups,treated with Aripiprazole or Risperidone for 12 weeks.The positive and negative syndrome scale(PANSS) and treatment emergent symptoms scale(TESS) were used to evaluate efficacy and adverse effects respectively before and at the ends of 2,4,8,12 weeks of treatment.Results:The therapeutic efficacy in Aripiprazol... |
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| Keywords: | Aripiprazole Risperidone Schizophrenia |
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