硫酸镁防治蛛网膜下腔出血后脑血管痉挛的疗效观察

目的:观察硫酸镁防治蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的疗效。方法:将SAH患者54例,随机分为治疗组(28例)和对照组(26例)。对照组采用脱水、止血等常规疗法;治疗组在常规疗法基础上加用25%硫酸镁15ml加生理盐水250ml,静脉滴注,2次/天;10天后改为1次/天,再用10天停用。采用经颅多普勒(TCD)检测SAH患者脑动脉的收缩峰速度,观察各组CVS发生的情况。结果:治疗组继发CVS 4例(14.3%),对照组13例(50%)。治疗组患者脑动脉的收缩率流速(Vp)较对照组差异极有显著性(P<0.01);且治疗后与治疗前Vp相经差异极有显著性(P<0.01);对照组患者治疗前后的Vp相比差异无显著性(P>0.05)。结论:硫酸镁防治SAH后CVS疗效确切。

Clinical observation of the effect of mgnesim sulfate in the treatment and prevention of cerebral vasospasm after subarachnoid hemorrhage

Objective:To investigate the curative effect of magnesium sulfate in the treatment and prevention of cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH).Methods:54 patients with SAH were randomized into two groups,the treatment group(28 cases) and control group(26 cases).The routine therapy was used in both groups,besides this the treatment group was added with magnesium sulfate.All the patients were detected by transcranial Doppler scanning.Results:Suffered from CVS after SAH,there were 4 cases accounting for 14.3% in the treatment group and 13 cases accounting for 50% in the control group.The contracting peak velocity(Vp) of cerebral arteries after treatment with magnesium sulfate changed more significantly compared with that of the control group(P<0.01),and also with that before treatment(P<0.01).The difference before and after treatment was not significant in the control group(P>0.05).Conclusion:The curative effect of magnesium sulfate in the treament and prevention of cerebral vasospasm after subarachnoid hemorrhage is definete.