基于多元线性回归的癫痫患儿丙戊酸血药浓度影响因素分析

目的：探讨影响癫痫患儿丙戊酸（VPA）的血药浓度的因素。方法：回顾性分析我院218例VPA血药浓度监测报告，包括患儿性别、年龄、丙戊酸钠日总剂量、联合用药情况、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血浆白蛋白、血肌酐和稳态血药浓度。利用多元线性回归分析影响VPA血药浓度变化的因素。结果：多元线性回归分析显示，日总剂量与血药浓度呈正相关（P<0.05），白蛋白含量与血药浓度呈负相关（P<0.05），不同剂型对血药浓度有影响，丙戊酸钠缓释片与糖浆的血药浓度比较差异有统计学意义（P<0.05）。结论：丙戊酸钠的不同剂型、给药剂量和白蛋白含量会影响VPA血药浓度，患儿性别、年龄、是否联用左乙拉西坦或拉莫三嗪、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血肌酐与血药浓度无相关性

Influencing Factors of Serum Valparaiso Acid Concentration in Children with Epilepsy Based on Multiple Linear Regression

Objective: To probe into the influencing factors of serum valparaiso acid (VPA) concentration in children with epilepsy. Methods: Retrospective analysis was performed on reports of 218 cases of VPA concentration monitoring in our hospital, including gender, age, total daily dose of valproate, drug combination, alanine aminotransferase, aspartate aminotransferase, plasma albumin, serum creatinine and steady-state serum concentration. Multivariate linear regression analysis was used to analyze the factors affecting the changes of VPA. Results: Multivariate linear regression analysis showed that the daily total dose was positively correlated with the serum drug concentration (P<0.05), the total protein content was negatively correlated with the serum drug concentration (P<0.05). Different dosage forms had various influences on serum concentration, and the difference in serum concentration between valproate delayed-release tablets and syrup was statistically significant (P<0.05). Conclusion: VPA concentration is influenced by different dosage forms, dosage and total protein content of sodium valproate. There is no correlation between serum concentration and gender, age, drug combination with levetiracetam or lamotrigine, alanine aminotransferase, aspartate aminotransferase and serum creatinine