| 阿藿烯对四氯化碳所致大鼠肝纤维化的保护作用 |
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| 引用本文： | 张晓林,赵树进,杨安平,张相年,翁闪凡. 阿藿烯对四氯化碳所致大鼠肝纤维化的保护作用[J]. 营养学报, 2011, 33(4) |
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| 作者姓名： | 张晓林 赵树进 杨安平 张相年 翁闪凡 |
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| 作者单位： | 1. 佛山科学技术学院医学院,佛山,528000
2. 广州华博生物制药研究所,广州,510010 |
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| 基金项目： | 广东省自然科学基金项目 |
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| 摘 要： | 目的探讨阿藿烯对四氯化碳(CCl4)所致大鼠肝纤维化的保护作用。方法将40只SD大鼠随机分为对照组、模型组、低(25mg/kg)和高剂量(50mg/kg)阿藿烯组,用40%CCl4皮下注射制作肝纤维化模型,阿藿烯按低和高剂量分别连续灌胃6w后,检测血清丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)活性、总蛋白(TP)和清蛋白(ALB)含量、总胆红素(TBIL)和间接胆红素(DBIL)及肝纤维化的透明质酸(HA)和层粘连蛋白(LN)水平;检测肝组织超氧化物歧化酶(SOD)活性和脂质过氧化(MDA)水平;并进行肝脏组织病理学检查。结果低、高剂量组阿藿烯均可显著降低血清ALT和AST活性、TBIL、DBIL、HA和LN水平(P<0.01或P<0.05);增加ALB含量(P<0.05);提高肝脏SOD活性和减少MDA含量(P<0.01);并明显改善肝脏的纤维化程度(P<0.01或P<0.05)。结论阿藿烯能够减轻CCl4所致的大鼠肝纤维化作用,其机制可能与抗氧化作用有关。
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| 关 键 词： | 阿藿烯 肝纤维化 抗氧化作用 四氯化碳 |
THE PROTECTIVE EFFECT OF AJOENE ON HEPATIC FIBROSIS INDUCED BY CARBON TETRACHLORIDE IN RATS |
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| ZHANG Xiao-lin,ZHAO Shu-jin,YANG An-ping,ZHANG Xiang-nian,WENG Shan-fan. THE PROTECTIVE EFFECT OF AJOENE ON HEPATIC FIBROSIS INDUCED BY CARBON TETRACHLORIDE IN RATS[J]. Acta Nutrimenta Sinica, 2011, 33(4) |
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| Authors: | ZHANG Xiao-lin ZHAO Shu-jin YANG An-ping ZHANG Xiang-nian WENG Shan-fan |
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| Affiliation: | ZHANG Xiao-lin,ZHAO Shu-jin1,YANG An-ping,ZHANG Xiang-nian1,WENG Shan-fan (Medical School,Foshan University,Foshan 528000,1 Bio-Pharmaceutical Institute of Guangzhou,Guangzhou 510010,China) |
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| Abstract: | Objective To study the protective effect of ajoene on hepatic fibrosis induced by carbon tetrachloride(CCl4)in rats and explore its possible mechanism.Method Forty male Sprague-Dawley rats were divided randomly into four groups: control group,model group,low ajoene group and high ajoene group.The model group was induced by injection of 40% CCl4 2 times per week for 6 w.Low and high ajoene groups were administered with ajoene 25 or 50mg/(kg.d) for 6 w.At the end of the sixth week,serum alanine aminotransfera... |
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| Keywords: | ajoene hepatic fibrosis antioxidation carbon tetrachloride |
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