艾可合剂对兔体外膀胱和前列腺尿道平滑肌的弛缓作用

Objective:To observe the relaxant effect of Aike Mixture(艾可合剂,AKM)on isolated bladder and prostatic urethral smooth muscle of rabbits.Methods:The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed in a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system.The effects of AKM in combination with methoxyamine,carbachol and CaCl_2 on the contractile tension of muscle strips were determined by cumulative dosing.Results:AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle(r=0.831,P0.05),reduced contractile wave amplitude(r=0.837,P0.05)and decreased contractile frequency(r=-0.917,P0.01).AKM significantly inhibited the increases in smooth muscle contraction induced by methoxyamine,carbachol and CaCl_2.Conclusion:AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.