Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development |
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| Authors: | Lucas H Sampaio Mariane MA Stefani Regiane M Oliveira Ana LM Sousa Greg C Ireton Steven G Reed Malcolm S Duthie |
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| Affiliation: | 1.Tropical Pathology and Public Health Institute,Federal University of Goiás,Goiania,Brazil;2.Infectious Disease Research Institute,Seattle,USA |
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| Abstract: | Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae that can manifest a wide variety of immunological and clinical outcomes ranging from potent humoral responses among borderline lepromatous (BL) and lepromatous (LL) patients to strong cellular responses among tuberculoid (TT) and borderline tuberculoid (BT) patients. Until recently, relatively little has been known about the immune responses to individual proteins of M. leprae recognized during leprosy. |
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