| PD-1信号通路和CTLA-4在眼科领域的研究进展 |
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| 引用本文： | 孟倩丽,吕正. PD-1信号通路和CTLA-4在眼科领域的研究进展[J]. 眼科新进展, 2021, 0(1): 001-5. DOI: 10.13389/j.cnki.rao.2021.0001 |
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| 作者姓名： | 孟倩丽 吕正 |
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| 作者单位： | 510080 广东省广州市，广东省人民医院（广东省医学科学院）眼科，广东省眼病防治研究所(孟倩丽,吕正)；515100 广东省广州市，华南理工大学医学院(孟倩丽,吕正) |
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| 基金项目： | 广东省自然科学基金项目(编号2019A1515010697);广州市科技计划项目(编号202002030400);广东省医学科学技术研究基金项目(编号A2019380)。 |
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| 摘 要： | 免疫疗法的深入研究及广泛应用显著推动了肿瘤学的发展。其中针对程序性死亡分子-1（programmed cell death protein-1，PD-1）和细胞毒性T淋巴细胞抗原-4（cytotoxic T-lymphocyte antigen-4,CTLA-4）的免疫治疗药物已成为生物制药和肿瘤治疗领域的研究热点。有关PD-1信号通路和CTLA-4在眼科领域的研究也取得了较大进展。本文就近年来关于PD-1信号通路和CTLA-4在眼生理病理方面的研究进展以及临床应用此类免疫抑制剂后出现的眼部相关不良反应进行总结、分析和述评。
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| 关 键 词： | 程序性死亡分子-1 细胞毒性T淋巴细胞抗原-4 自身免疫性眼病 代谢病相关眼病 免疫检查点抑制剂 |
Advance of PD-1 signaling pathways and CTLA-4 in ophthalmology |
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| MENG Qianli,LV Zheng. Advance of PD-1 signaling pathways and CTLA-4 in ophthalmology[J]. Recent Advances in Ophthalmology, 2021, 0(1): 001-5. DOI: 10.13389/j.cnki.rao.2021.0001 |
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| Authors: | MENG Qianli LV Zheng |
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| Affiliation: | 1.Guangdong Eye Institute,Department of Ophthalmology,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080, Guangdong Province,China2.School of Medicine,South China University of Technology,Guangzhou 515100, Guangdong Province,China |
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| Abstract: | In recent decades,immunotherapy has significantly promoted the development of the field of oncology.The immunotherapeutic drugs targeting programmed cell death protein-1(PD-1)and cytotoxic T-lymphocyte antigen-4(CTLA-4)have become the focus of biopharmaceuticals and tumor therapy.Much progress has also been made in the study on PD-1 and CTLA-4 signaling pathways in ophthalmology.This paper reviewed recent advances in the study of PD-1 and CTLA-4 signaling pathways in the physiological and pathological processes of the eye and the side effects of eye-related diseases after treatment with these inhibitors. |
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| Keywords: | programmed cell death protein-1 cytotoxic T-lymphocyte antigen-4 ocular autoimmune diseases metabolic diseases associated ocular disease immune checkpoints inhibitors |
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