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The effect of methamphetamine on histamine release in the rat hypothalamus |
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| Authors: | CHIHIRO ITO MD KENJI ONODERA PHD ATSUSI YAMATODANI MD TAKEHIKO WATANABE MD MITSUMOTO SATO MD |
| Affiliation: | Departments of Psychiatry, Suita, Japan;Pharmacology I, Tohoku University School of Medicine, Suita, Japan;Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Suita, Japan;Department of Medical Physics, School of Allied Health Sciences, Osaka University Faculty of Medicine, Suita, Japan |
| Abstract: | Abstract In the present study, the effect of methamphetamine (MAP) on histamine (HA) release measured by in vivo brain microdialysis in the rat hypothalamus was investigated. Administration of MAP (3 mg/kg) significantly increase HA release from 40 to 160 min after the injection. This finding suggests that a moderate dose of MAP activates the hypothalamic HA neuron system, which may be related to effects of MAP on intrinsic biological rhythms. |
| Keywords: | histamine release hypothalamus in vivo brain microdialysis methamphetamine |