| 硒蛋白及其基因多态性研究进展 |
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| 引用本文： | 熊咏民.硒蛋白及其基因多态性研究进展[J].国外医学：医学地理分册,2010,31(4):211-215. |
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| 作者姓名： | 熊咏民 |
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| 作者单位： | 西安交通大学医学院地方病研究所,环境与相关基因教育部重点实验室,陕西西安,710061 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 硒是人体必需的微量元素,在维持细胞活性和机体正常生理功能中发挥着重要作用。硒主要以硒代半胱氨酸的形式掺入形成蛋白质。其中硒代半胱氨酸是鉴定出的第21个氨基酸,并在核糖体蛋白合成中发挥重要作用。目前至少有25种硒蛋白在人类基因组中被鉴定。而且多项研究已证实硒蛋白基因多态性与多种疾病易感性存在相关关系。故作者就几种主要的硒蛋白及其基因多态性作一述评。
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| 关 键 词： | 硒 硒蛋白 多态性 |
Research progress in selenoproteins and theirs gene polymorphisms |
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| XIONG Yong-min.Research progress in selenoproteins and theirs gene polymorphisms[J].Foreign Medical Sciences(Section of Medgeography),2010,31(4):211-215. |
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| Authors: | XIONG Yong-min |
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| Institution: | XIONG Yong-min (Institute of Endemic Disease, Key Laboratory Environment Endueation, Xi＇ an Jiaotong University, and Genes Related to Diseuse, Ministry of Xi＇an 710061 ,China) |
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| Abstract: | The trace element selenium is an essential trace element and it play important roles in maintaining cellular activities and physiological function in human. Selenium which occurs in proteins in the main form of Selenocysteine （Se-Cys）-identified as the 21st amino acid used in ribosome-mediated protein synthesis-is incorporated in at least 25 specific, genetically determined human selenoproteins, many of which have only recently been discovered. Furthermore, the possible associations between polymorphisms of selenoprotein genes and disease susceptibility. In this review we provide a brief but up-to-date overview of what is currently known about some acknowledged human selenoproteins and their genetic polymorphisms. |
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| Keywords: | selenium selenoprotein polymorphism |
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