| 逍遥散对小鼠学习记忆能力的影响 |
| |
| 引用本文： | 瞿礼萍,曾南,卢陆飞,张崇燕,吴纯梅,蒲红霞. 逍遥散对小鼠学习记忆能力的影响[J]. 中药药理与临床, 2008, 24(6) |
| |
| 作者姓名： | 瞿礼萍 曾南 卢陆飞 张崇燕 吴纯梅 蒲红霞 |
| |
| 作者单位： | 成都中医药大学药学院,成都,610075 |
| |
| 基金项目： | 成都中医药大学校基金重点项目 |
| |
| 摘 要： | 目的:观察逍遥散对正常小鼠及记忆障碍小鼠学习记忆能力的影响,探讨其是否具有改善学习记忆能力的作用.方法:Morris水迷宫法观察逍遥散连续给药21d对正常小鼠空间学习记忆能力的影响;避暗法观察逍遥散对东莨菪碱、亚硝酸钠、乙醇及利血平所致记忆障碍模型小鼠学习记忆能力的影响.结果:Morris水迷宫实验表明,逍遥散30g/kg可明显提高正常小鼠空间学习记忆能力.避暗实验结果表明,逍遥散30、20g/kg对利血平所致记忆获得与亚硝酸钠所致记忆巩固障碍有保护作用,但对东莨菪碱、乙醇造成的小鼠记忆障碍作用不明显.结论:逍遥散具有一定增强和改善学习记忆能力的作用,其机制可能与影响单胺类递质及抗氧化、改善脑内血液循环有关.
|
| 关 键 词： | 逍遥散 学习记忆 Morris水迷宫 避暗法 |
Effects of Xiaoyao Powder(逍遥散) on learning and memory function in mice |
| |
| Qu Liping,Zeng Nan,Lu Lufei,Zhang Chongyan,Wu Chunmei,Pu Hongxia. Effects of Xiaoyao Powder(逍遥散) on learning and memory function in mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 2008, 24(6) |
| |
| Authors: | Qu Liping Zeng Nan Lu Lufei Zhang Chongyan Wu Chunmei Pu Hongxia |
| |
| Affiliation: | Qu Liping,Zeng Nan,Lu Lufei,Zhang Chongyan,Wu Chunmei,Pu Hongxia(College of Pharmacy,Chengdu University of TCM,Chengdu 610075) |
| |
| Abstract: | Objective To observe the effects of Xiaoyao Powder on learning and memory function in normal and memory disordered mice.Methods Morris maze test was used to evaluate the effect of Xiaoyao Powder on special learning and memory function in normal mice.Step-through test was applied to observe its effect on learning and memory function in memory disordered mice,which induced by scopolamine hydrobromide,reserpine,NaNO2 and ethanol.Results Xiaoyao Powder(30g/kg)intragastricly administrated for 21d could improve t... |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
