| 青藤碱微乳凝胶的制备及体外透皮特性研究 |
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| 引用本文： | 王利胜,张升,刘丽萍,赖宝林,夏祖猛,吴阳,程龙,田瑶. 青藤碱微乳凝胶的制备及体外透皮特性研究[J]. 中药新药与临床药理, 2011, 22(1) |
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| 作者姓名： | 王利胜 张升 刘丽萍 赖宝林 夏祖猛 吴阳 程龙 田瑶 |
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| 作者单位： | 广州中医药大学药剂学教研室,广州,510006 |
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| 基金项目： | 国家自然基金资助，广州中医药大学本科创新基金资助 |
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| 摘 要： | 目的 制备青藤碱微乳凝胶,并对其进行质量评价和体外透皮扩散特性进行考察.方法 以卡波姆940为基质,采用直接溶胀法制备青藤碱微乳凝胶.采Zetasizer1000-HAS激光粒度测定仪测定微乳凝胶的粒度分布.采用NDJ-7旋转黏度计和pH计分别测定微乳凝胶的黏度和pH.采用改良Franz扩散池,比较青藤碱微乳、微乳凝胶及亲水凝胶中青藤碱的透皮特性.结果 青藤碱微乳凝胶外观为透明金黄色溶液,粒度分布在4～15nm范围内,pH 6.5左右,黏度为2.0 pa's,稳定性良好.青藤碱对照水溶液、微乳、微乳凝胶、亲水凝胶的稳态渗透速率分别为3.328,42.861,17.244,12.185 μg·cm-2·h-1,12 h的累积渗透量分别为41.104 4±1.219, 505.198±176.964,211.373±24.856,145.391±24.392μg·cm-2结论青藤碱微乳、微乳凝胶的12 h累积渗透量和渗透速率均优于青藤碱对照水溶液和亲水凝胶,可为青藤碱经皮给药剂型选择提供参考.
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| 关 键 词： | 青藤碱 微乳凝胶 体外透皮 |
Preparation and In-vitro Transdermal Properties of Sinomenine Microemulsion-based Gel |
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| WANG Lisheng,ZHANG Sheng,LIU Liping,LAI Baolin,XIA Zumeng,WU Yang,CHENG Long,TIAN Yao. Preparation and In-vitro Transdermal Properties of Sinomenine Microemulsion-based Gel[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(1) |
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| Authors: | WANG Lisheng ZHANG Sheng LIU Liping LAI Baolin XIA Zumeng WU Yang CHENG Long TIAN Yao |
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| Affiliation: | WANG Lisheng,ZHANG Sheng,LIU Liping,LAI Baolin,XIA Zumeng,WU Yang,CHENG Long,TIAN Yao(Department of Pharmacy,Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To prepare the microemulsion-based gel of sinomenine,and to study its quality evaluation and transdermal diffusion characteristics in vitro.Methods With Carbopol 940 as a substrate,we prepared microemulsion-based gel of sinomenine by direct swelling method.The particle size distribution of microemulsion-based gel was detected with Zetasizer1000-HAS particle size laser analyzer.The viscosity of microemulsion-based gel was measured with NDJ-7 rotating viscometer,and the pH value was detected with pH... |
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| Keywords: | Sinomenine Microemulsion-based gel Transdermal in vitro |
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