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| 骨形态发生蛋白7在肾脏发育及肾脏疾病中的作用 | |
| 引用本文： | 郝旭. 骨形态发生蛋白7在肾脏发育及肾脏疾病中的作用[J]. 医学综述, 2011, 17(4): 504-507 |
| 作者姓名： | 郝旭 |
| 作者单位： | 上海交通大学医学院附属瑞金医院肾内科,上海,200025 |
| 摘 要： | 骨形态发生蛋白7(BMP-7)作为一种成骨蛋白,是转化生长因子β超家族的成员。BMP-7起初被认为具有诱导骨的生成,随后发现其具有明显的肾脏保护作用。在肾脏发育过程中,BMP-7可以诱导输尿管芽的发生及肾小球的形成。此外,在肾脏疾病中BMP-7可以通过Smad通路拮抗转化生长因子β诱导的肾小管上皮细胞间充质转分化,而在肾脏纤维化、糖尿病肾病等肾脏疾病中发挥重要作用。 |
| 关 键 词： | 骨形态发生蛋白7 转化生长因子β 上皮细胞间质转分化 纤维化 肾脏疾病 |
Role of BMP-7 in Kidney Development and Kidney Disease |
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| HAO Xu. Role of BMP-7 in Kidney Development and Kidney Disease[J]. Medical Recapitulate, 2011, 17(4): 504-507 | |
| Authors: | HAO Xu |
| Affiliation: | HAO Xu,WANG Wei-ming,CHEN Nan.(Department of Nephrology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China) |
| Abstract: | As an osteogenic protein,bone morphogenetic protein-7（BMP-7）is a member of the transforming growth factor-β（TGF-β）superfamily.BMP-7 was regarded to play important roles in induction of bone formation initially,subsequent research reveal its role in renoprotection.In the development of kidney,BMP-7 can induce the genesis of ureteric duct and glomeruli.In addition,BMP-7 can protect kidney by antagonist EMT induced by TGF-β through Smad pathway in kidney disease,such as renal fibrosis,diabetic nephropathy and etc. |
| Keywords: | Bone morphogenetic protein-7 Transforming growth factor-β Epithelial mesenchymal transition Fibrosis Kidney disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |