川崎病疑似病例早期治疗探讨

目的:探讨引用“川崎病疑似病例”这一概念,对实现川崎病早期用阿司匹林(ASP)及大剂量静注丙种球蛋白(IVIG)治疗的实用性和可行性。方法:对入选的36例川崎病疑似病例早期应用ASP和IVIG治疗,并对临床资料进行分析总结。结果:36例中最后有32例确诊为川崎病,初诊时确诊5例,约占13.9%,其余为疑似病例,在平均病程6.93d开始上述治疗,比平均确诊日期(10.32d)明显提前,冠状动脉损害发生率为6.25%,明显低于传统治疗。最后诊断非川崎病的4例未因上述治疗加重或延误病情。结论:引用川崎病疑似病例这一概念,能有效实现早期应用ASP、IVIG治疗川崎病,降低冠状动脉损害发生率,安全实用可行。

Exploration for Early Treatment of Suspected Cases of Kawasaki Disease

Objective:To quote a concept of “Suspected Case of Kawasaki Disease” in order to define the practicability and feasibility of early treatment of it with ASP and IVIG in high dosage by IV push.Methods: 36 suspected cases of Kawasaki disease(KD) were treated with ASP and IVIG at the early stage,and then the clinical data were analysed and summarized.Results:From 36 suspected cases,32 cases were confirmed to suffer from KD. When first diagnosed 5 cases(13.9%) were proven to have this disease,and the remainders were suspected.After 6.93 days(at average)of the disease onset the aforementioned treatment began to be undertaken.The time of first visit to a doctor was earlier than the average visit time(10.32 days),and the incidence of coronary lesion(6.25%)was lower than that taken out by traditional treatment.In the four cases of non-KD which was diagnod at last the disease was not worsening because of above treatment.Conclusion:Quoting the concept of Suspected Cases of KD can successfully help the doctor to early cure the disease with ASP and IVIG,thus decreasing the incidence of coronary lesion.