Combination of dacarbazine,mitomycin C, 5-fluorouracil and vincristine in advanced colorectal cancer |
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| Authors: | Geoffrey Falkson H. L. Pretorius H. C. Falkson H. S. Schoeman |
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| Affiliation: | (1) Department of Cancer Chemotherapy, H F Verwoerd Hospital, Private Bag X169, 0001 Pretoria, Republic of South Africa;(2) University of Pretoria, Private Bag X169, 0001 Pretoria, Republic of South Africa |
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| Abstract: | ![]()
Summary Thirty patients with advanced measurable colorectal cancer received monthly courses of a combination of dacarbazine, mitomycin C, 5-fluorouracil, and vincristine (FIV Mit-Or). Four of the patients had received prior chemotherapy. Two patients were not evaluable for response. Objective response was obtained in four patients. Severe toxicity was encountered in 11 patients. It is concluded that unlike the fourdrug combination of 5-fluorouracil, DTIC, vincristine and BCNU (FIVB), the present regimen did not have significant antitumour activity in advanced colorectal cancer. |
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