全身炎症反应综合征在新生儿肺出血时临床意义

为探讨全身炎症反应综合征(SIRS)在新生儿肺出血疾病演变与转归中的意义,将94例肺出血新生儿分为SIRS组68例和非SIRS组26例,比较其病死率及SIRS组中SIRS持续时间及各脏器功能不全等与肺出血的关系。结果提示,非SIRS组肺出血病死率远低于SIRS组(P<0.01);符合SIRS诊断标准项目4项者,病死率远高于2、3项者(P<0.05);随着功能不全器官数目的增多及器官损害的严重性,肺出血病死率不断增加。提示,SIRS的发生、持续时间、并发功能不全器官数目及器官损害的严重性,均影响肺出血的预后,为此必须预防和及早控制SIRS,防止其进一步恶化导致肺出血及多脏器功能衰竭。

Clinical significance of the systemic inflammatory response syndrome on newborn infants with pulmonary hemorrhage

To explore clinical significance of systemic inflammatory response syndrome(SIRS) on the evolvement and outcome in newborn infants with pulmonary hemorrhage, 94 patients suffered from neonatal pulmonary hemorrhage were stratified into SIRS group(68 cases)and non-SIRS group(26 cases).The mortality in SIRS group was compared with that in non-SIRS group, and also the relationship between the severity of the pulmonary hemorrhage and duration of SIRS or multiple organs dysfunction syndrome in SIRS group was studied.The results indicated the mortality in pulmonary hemorrhage in non-SIRS group was significantly lower than that in SIRS group(P<0.01) . If the infants had 4 items of the diagnostic criteria for SIRS, the mortality was significantly higher than those only with 2 or 3 item's(P<0.05) .With the number of the organ dysfunction increasing and the severity of organ dysfunction aggravated, the mortality for newborn infants with pulmonary hemorrhage will be increasing. Multiple factors can influence on the prognosis of the newborn infants with pulmonary hemorrhage such as attacks of SIRS.The duration of SIRS lasted, the number of dysfunctional organs and the severity of the organ dysfunction. So attention must be paid to prevent and control the attack of SIRS as early as possible and interrupt it from aggravating to pulmonary hemorrhage and multi-organ failure.