硝苯地平缓释片联合厄贝沙坦氢氯噻嗪治疗高血压病疗效观察

目的:探讨硝苯地平缓释片联用厄贝沙坦氢氯噻嗪治疗高血压病的临床疗效。方法:采取随机双盲对照法,将80例高血压病患者随机分为两组,治疗组患者口服硝苯地平缓释片20mg/次,每12h一次,厄贝沙坦氢氯噻嗪150mg,1次/d,疗程为20周;对照组患者只口服硝苯地平缓释片,剂量方法同治疗组,同时控制每日摄入热量。观察两组患者治疗前后血压情况。结果:治疗组患者总有效率90%,对照组患者总有效率25%,经统计学处理有显著差异(P<0.05)。结论:硝苯地平缓释片与厄贝沙坦氢氯噻嗪联合用药可提高血压控制率。

Observation of effects of Irbesartan and Hydrochlorothiazide combined with Nifedipine sustained-release tablets on hypertension

Objective：To explore the clinical effect of Irbesartan and Hydrochlorothiazide combined Nifedipine sustained re-lease tablets on hypertension. Methods：According to a randomized, double blind controlled method, all 80 patients with primary hy-pertension were divided into treatment group and control group. The control group was given Nifedipine sustained - release tablets （20mg, oral treatment, one time/ 12 hours） and energy restriction, while the observation group was given Irbesartan and Hydrochlo-rothiazide （150 mg, oral treatment, once a day for 20 weeks） on the basis of that of the control group, but without energy restriction. The blood pressure was compared before and after the treatment. Results： The efficiency of observation group （90% ） was significantly higher than that of control group （25% ）, and there was a significant statistical difference between the two groups （P〈0. 05）. Conclu-sions： Irbesartan and Hydrochlorothiazide combined Nifedipine sustained release tablets can raise the control rate of hypertension.