Histology-Based Assessment of Sonazoid-Enhanced Ultrasonography for the Diagnosis of Liver Metastasis |
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| Authors: | Kazufumi Kobayashi Hitoshi Maruyama Soichiro Kiyono Osamu Yokosuka Masayuki Ohtsuka Masaru Miyazaki Jun Matsushima Takashi Kishimoto Yukio Nakatani |
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| Institution: | 1. Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan;2. Department of General Surgery, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan;3. Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan;4. Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan |
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| Abstract: | This retrospective study aimed to assess the diagnostic performance of contrast-enhanced ultrasound with Sonazoid (S-CEUS) for liver metastasis. We enrolled in this study 98 patients with 148 histologically proven liver lesions, with 121 metastases and 27 non-metastases. The S-CEUS technique showed sensitivity in 95.0% (115 of 121), specificity in 44.4% (12 of 27) and accuracy in 85.8% (127 of 148) for the diagnosis of metastasis. Higher body mass index had a negative influence on the positive predictive value and accuracy, and a greater depth of the lesion had a negative influence on the accuracy. The management was changed in 8 patients (8.2%) because of S-CEUS findings. In conclusion, the addition of S-CEUS may offer a great benefit by improvement of the quality of diagnosis and management for patients with cancer who have a tentative diagnosis of liver metastasis by contrast-enhanced computed tomography. |
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| Keywords: | Contrast-enhanced ultrasound Sonazoid Liver metastasis Diagnostic performance |
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