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Thin Glomerular Basement Membrane in a Kidney Transplant of an Alport's Syndrome Patient: A Case Report |
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| Authors: | S. Santos S. Marques T. Golper A. Langone A.B. Fogo |
| Affiliation: | 1. Department of Nephrology, Centro Hospitalar do Porto, Porto, Portugal;2. Department of Nephrology, Hospital São João, Porto, Portugal;3. Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA;4. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| Abstract: | Alport syndrome (AS) and thin basement membrane lesions are caused by various mutations in type IV collagen genes. Although AS is considered a rare disease, thin basement membrane is a frequent pattern, especially in families with a history of persistent hematuria. We report a patient with a diagnosis of AS who developed end-stage kidney disease (ESKD) and received a kidney transplant from a living unrelated donor. The graft biopsy specimen surprisingly showed a pattern of thin basement membranes. |
| Keywords: | Address correspondence to Sofia Santos MD Department of Nephrology Centro Hospitalar do Porto Largo Prof. Abel Salazar Porto 4099-001 Portugal. |
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