| 红细胞内、外钠和内外钠差的一般水平与血压的关系 |
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| 引用本文： | 潘小琴,刘竹青,金玉环,王荣学. 红细胞内、外钠和内外钠差的一般水平与血压的关系[J]. 华中科技大学学报(医学版), 1985, 0(2) |
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| 作者姓名： | 潘小琴 刘竹青 金玉环 王荣学 |
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| 作者单位： | 武汉医学院卫生系流行病学教研室(潘小琴，刘竹青)，大冶钢厂职工医院防治科(金玉环)，大冶钢厂职工医院防治科(王荣学) |
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| 摘 要： | 本文调查研究了一个确定的人群—某工厂电气车间221名男女工人的红细胞内、外钠和内外钠差的水平和分布,并用多因子回归和逐步回归分析了它们与血压的关系。结果:1.部分高血压病例和有家族史的血压正常者有红细胞内钠增高和钠净排出量减少现象。2.有家族史的血压正常者的血浆钠浓度与收缩压和舒张压均有正的联系,而无家族史者不明显。3.有家族史者红细胞内外钠差与血压(特别是收缩压)有负的联系,无家族史者则否。提示:高血压患者及其子代存在细胞膜遗传性钠转运异常,可能是高血压的一个病因。
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| 关 键 词： | 高血压 遗传学标记 细胞外钠 细胞内钠 细胞膜内外钠差 |
General Level and Distribution of the Intra-and Extra-erythrocytes Sodium Concentration in a Populationand their Relationship with Blood Pressure |
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| Pan Xiaoqin,Liu Zuqing. General Level and Distribution of the Intra-and Extra-erythrocytes Sodium Concentration in a Populationand their Relationship with Blood Pressure[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1985, 0(2) |
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| Authors: | Pan Xiaoqin Liu Zuqing |
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| Affiliation: | Pan Xiaoqin,Liu ZuqingDepartment of Epidemiology,Faculty of Public Health,Wuhan Medical College,WuhanJin Yuhuan,Wang RongxueDepartment of Prevention and Cure,Daye Steel Plant Worker's Hospital,Hubei Province |
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| Abstract: | This paper reports a cross-sectional survey in a defined population.The level and distribution of intraerythrocyte sodium ions (Na i) and extraerythrocyte sodium ions (Na e) of 221 male and female workers were studied and their relationship with blood pressure was analysed by multiple and step-wise regression.The results suggested that:(1) A part of hypertensives and their descendents with normal blood pressure had abnormal sodium trasport phenomenon in their erythrccytes membrane.(2) Plasma Na concentration was positively correlated with the blood pressure of normctensives especially those with family hypertension history.(3) The difference between Na i and Na e concentrations was negatively correlated with blood pressure (especially on SBP) of the descendents of hypertensives.(4) These effects were much greater than those produced by known factors such as sex,age,weight and height. |
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| Keywords: | hypertension genetic marker Na e Na i Na e-i |
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