| 代谢型谷氨酸受体与吗啡耐受和依赖 |
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| 引用本文： | 刘金变,江伟. 代谢型谷氨酸受体与吗啡耐受和依赖[J]. 国际麻醉学与复苏杂志, 2009, 30(1). DOI: 10.3760/cma.j.issn.1673-4378.2009.01.025 |
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| 作者姓名： | 刘金变 江伟 |
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| 作者单位： | 上海交通大学第六人民医院麻醉科,200233;上海交通大学第六人民医院麻醉科,200233 |
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| 摘 要： | 谷氨酸通过离子型和代谢型谷氨酸受体(metabotropic Slutmate receptors,mGluRs)发挥作用,其中mGluRs是G蛋白耦联受体,分为3组共8个亚型,通过突触前和突触后作用参与离子通道活动调节、神经递质释放、突触传递和突触町塑性等生理病理过程.研究表明mGluRs与吗啡耐受和依赖密切有关.现就近年来各种类型的mGluRs参与吗啡耐受和依赖的研究进展作一综述.
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| 关 键 词： | 谷氨酸 代谢型谷氨酸受体 吗啡耐受 |
Involvement of metabotropic glutamate receptor in morphine tolerance and dependence |
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| LIU Jin-bian,JIANG Wei. Involvement of metabotropic glutamate receptor in morphine tolerance and dependence[J]. international journal of anesthesiology and resuscitation, 2009, 30(1). DOI: 10.3760/cma.j.issn.1673-4378.2009.01.025 |
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| Authors: | LIU Jin-bian JIANG Wei |
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| Abstract: | Glutamate mediates its effects via both ionotropie and metabotropic receptors. Metabotropic glutamate receptors (mGluRs) include eight subtypes and are classified into three major groups. G protein-coupled mGluRs modulate function of ion channel, neurotransmitter releasing, synapse transmission and plasticity through pre-and post-synaptic sites. Recent evidence supports the involvement of mGluRs in the development of morphine tolerance and dependence. This article reviewed the progress in differential role of mGluRs subtypes in morphine tolerance and dependence. |
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| Keywords: | Glutamate Metabotropic glutamate receptor Morphine tolerance |
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