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| 抗神经性毒剂药物—对称双吡啶季铵盐的合成 | |
| 引用本文： | 高凤兰 丁振kai. 抗神经性毒剂药物—对称双吡啶季铵盐的合成[J]. 军事医学科学院院刊, 1989, 13(3): 211-213 |
| 作者姓名： | 高凤兰 丁振kai |
| 作者单位： | 军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所 |
| 摘 要： | 本文报道了一类新的抗神经性毒剂化合物,对称的不含肟基的双吡啶季铵盐的合成.其中化合物A_4和A_7预防小鼠梭曼中毒的ED_(50)值分别为32和21.6mg/kg. |
| 关 键 词： | 双吡啶季铵盐 神经性毒剂 抗毒剂 |
STUDIES ON SYNTHESIS OF SYMMETRIC BISPYRID-INIUM SALTS AS ANTIDOTES FOR NERVE AGENTS POISONING |
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| Gao Fenglan,Ding Zhenkai,Song Hongqian Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences. STUDIES ON SYNTHESIS OF SYMMETRIC BISPYRID-INIUM SALTS AS ANTIDOTES FOR NERVE AGENTS POISONING[J]. Bulletin of the Academy of Military Medical Sciences, 1989, 13(3): 211-213 | |
| Authors: | Gao Fenglan Ding Zhenkai Song Hongqian Institute of Pharmacology Toxicology Academy of Military Medical Sciences |
| Abstract: | A series of symmetric bispyridinium salts as antidotes for nerve agents poisoning was synthesized and some of them possessed more potent prophylactic activities for soman poisoning in mice. |
| Keywords: | bispyridinium salts antidotes nerve agents soman |
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