| Cyclin D1在肝细胞癌中的表达及其临床意义 |
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| 引用本文： | 董俊峰,倪家连,吴小鹏.Cyclin D1在肝细胞癌中的表达及其临床意义[J].腹部外科,2009,22(1):55-56. |
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| 作者姓名： | 董俊峰 倪家连 吴小鹏 |
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| 作者单位： | 1. 济南军区总医院肝胆外科,250031
2. 山东大学齐鲁医院普外科 |
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| 摘 要： | 目的探讨Cyclin D1在肝细胞癌（HCC）组织中的表达及其意义。方法采用免疫组织化学S-P法检测50例HCC组织、20例正常肝组织中Cyclin D1蛋白的表达情况。结果Cyclin D1蛋白在肝癌组织中的阳性率为44．0％，极显著高于正常肝组织（均为阴性表达）（P〈0．01）；阳性表达与肝癌的肝内转移和肝癌的分化程度有关（P〈0．05，P〈0．05）。Cyclin D1的过表达均与病人术后〈3年生存期有关（P〈0．05）。结论Cyclin D1在HCC的发生、发展过程中起着不同程度的作用，检测Cyclin D1对判定HCC预后可提供一定的依据。
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| 关 键 词： | 癌 肝细胞 免疫组织化学 细胞周期素D1 |
Expression and clinical significance of Cyclin D1 protein in primary hepatocellular carcinoma |
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| DONG Jun-feng,NI Jia-lian,WU Xiao-peng.Expression and clinical significance of Cyclin D1 protein in primary hepatocellular carcinoma[J].Journal of Abdominal Surgery,2009,22(1):55-56. |
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| Authors: | DONG Jun-feng NI Jia-lian WU Xiao-peng |
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| Institution: | DONG Jun-feng,NI Jia-lian,WU Xiao-peng.Department of Hepatobiliary Surgery,Jinan Military Region General Hospital,Jinan 250031,China |
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| Abstract: | Objective To investigate the expression and significance of Cyclin D1 in primary hepatocellular carcinoma(HCC).Methods S-P immunohistochemical staining was performed to detect the expression of Cyclin D1 protein in 50 HCC tissues and 20 normal liver tissues.Results The positive rate of Cyclin D1 expression in HCC was 44.0 %,which was significantly higher than that in normal liver tissues (negative expression) (P<0.01).The expression of Cyclin D1 was correlated with intrahepatic dissemination and tumor grade... |
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| Keywords: | Carcinoma hepatocellular Immunohistochemistry Cyclin D1 |
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