Effects of Simvastatin on the Phospholipid Composition of High-Density Lipoproteins in Patients with Hypercholesterolemia |
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| Authors: | I. N. Ozerova I. V. Paramonova A. M. Olfer'ev N. M. Akhmedzhanov M. A. Aleksandrova N. V. Perova |
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| Affiliation: | (1) Department of Metabolic Disorders, State Research Center of Preventive Medicine, Russian Ministry of Health, Moscow |
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| Abstract: | ![]()
We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvastatin changed the concentration and phospholipid composition of high-density lipoproteins, which improved their cholesterol-accepting and cholesterol-transporting properties. |
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| Keywords: | lipoproteins phospholipids hypercholesterolemia simvastatin |
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