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浸浴结合人工生物敷料和重组牛成纤维细胞生长因子2治疗烧伤后期残余创面的观察
引用本文:高维东,刘旭盛,韩行,韩玉国,余继超. 浸浴结合人工生物敷料和重组牛成纤维细胞生长因子2治疗烧伤后期残余创面的观察[J]. 中华烧伤杂志, 2007, 23(1): 40-42
作者姓名:高维东  刘旭盛  韩行  韩玉国  余继超
作者单位:1. 解放军第二0六医院烧伤整形科,134001
2. 400038,重庆,第三军医大学西南医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室
摘    要:
目的观察浸浴结合人工生物敷料和重组牛成纤维细胞生长因子2(rb-FGF2)治疗烧伤后期残余创面的效果。方法将有烧伤后期残余创面的56例患者分为试验组(28例)和对照组(28例)。试验组患者浸浴后,将生物敷料覆盖于创面行半暴露疗法,用rb-FGF2喷湿敷料2次/d,每2~3天浸浴1次并更换敷料;对照组刨面消毒后仅以单层碘伏纱布覆盖行半暴露疗法。1个疗程(10d)结束后,比较两组患者的治愈率、有效率、创面细菌学情况及相关安全性指标。结果试验组和对照组患者的治愈率、有效率、细菌清除率分别为64.3%、89.3%、92.3%和32.1%、67.9%、72.0%,两组上述指标比较,差异均有统计学意义(P<0.01)。两组患者未发生不良反应。结论浸浴结合应用新型人工生物敷料和rb-FGF2治疗烧伤后期残余创面安全、有效,可控制创面感染、提高治愈率。

关 键 词:烧伤 生物敷料 成纤维细胞生长因子2 细菌感染 浸浴 残余创面
文章编号:23954766
修稿时间:2006-02-26

The application of artificial dermis and recombinant bFGF afer immersion bath in residual burn wound
GAO Wei-dong,LIU Xu-sheng,HAN Xing,HAN Yu-guo,YU Ji-chao. The application of artificial dermis and recombinant bFGF afer immersion bath in residual burn wound[J]. Chinese journal of burns, 2007, 23(1): 40-42
Authors:GAO Wei-dong  LIU Xu-sheng  HAN Xing  HAN Yu-guo  YU Ji-chao
Affiliation:Institute of Burn Research , Southwest Hospital, State Key Laboratry of Trauma, Burns and Combine Injury, the Third Military Medical University, Chongqing 400038, P. R. China
Abstract:
OBJECTIVE :To observe the effect of application of a new type of artificial biological dressing and recombinant bull fibroblast growth factor( rb-FGF2) after immersion bath in the treatment of residual infected burn wounds at late postburn stage. METHODS: Fifty-six patients with residual wounds at late postburn stage were enrolled in the study, and they were randomly divided into A( n = 28, experimental) and B (n = 28, control) groups. After treatment with immersion bath, the wounds in group A were treated with semi-exposure method. The wound were covered with suitable shape of biological dressings in suitable shape and rb-FGF2 spray twice a day after an immersion bath, and the dressing was changed every other day or every 2 days. To compare the treatment effect, the wounds in group B were only treated with a dressing of monolayer gauze wetted with povidone iodine. The clinical results, the bacteriological state findings, and the corresponding safety indices were determined 10 days after treatment. RESULTS: The wound healing rate, efficacy and the bacterial clearance rate in A group were 64. 3% ,89. 3% ,92. 3% , respectively, and they were obviously higher than those in B group (32. 1% , 67. 9% , 72. 0% , respectively, P < 0. 01 ). No adverse side-effects were observed in either group. CONCLUSION: Application of artificial dermis and bFGF after immersion bath is safe and effective for the elimination of residual wounds at late postburn stage, and it is also beneficial to control wound infection and promote the wound healing.
Keywords:Burns   Biological dressing   Fibroblast growth factor 2   Bacterial infection   Immersion bath    Residual wound
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