| 热休克蛋白22研究进展 |
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| 引用本文： | 陈琦,程晓曙. 热休克蛋白22研究进展[J]. 国际病理科学与临床杂志, 2006, 26(3): 14-237 |
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| 作者姓名： | 陈琦 程晓曙 |
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| 作者单位： | 南昌大学第二附属医院心血管内科,南昌大学心血管病研究所,南昌,33006;南昌大学第二附属医院心血管内科,南昌大学心血管病研究所,南昌,33006 |
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| 基金项目： | 江西省卫生厅科研项目 , 江西省自然科学基金 |
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| 摘 要： | A newly identified 22 kD protein, which is named as heat shock protein22 (HSP22), is a member of sHSP (small heat shock protein) subfamily. It contains the α-crystallin domain in its C-terminal half, a hallmark of the subfamily of sHSP. HSP22 has Ser-Thr protein kinase activity and chaperone-like activity. HSP22 is expressed in multiple tissues, specially in skeletal muscle, placenta and heart. Previous studies showed that HSP22 involved in growth and transformation of cells, apoptosis of tumor, hypertrophy and apoptosis of myocardial cells.
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| 关 键 词： | 热休克蛋白22 小热休克蛋白 生物学效应 |
| 文章编号： | 1673-2588(2006)03-0235-03 |
| 收稿时间： | 2005-04-12 |
| 修稿时间： | 2005-04-12 |
Research progress on heat shock protein 22 |
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| CHEN Qi,CHENG Xiao-shu. Research progress on heat shock protein 22[J]. Journal of International Pathology and Clinical Medicine, 2006, 26(3): 14-237 |
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| Authors: | CHEN Qi CHENG Xiao-shu |
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| Affiliation: | Department of Cardiology, Second Affiliated Hospital of Nanchang University,Institute of Cardiovascular Disease, Nanchang University, Nanchang 330006, China |
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| Abstract: | A newly identified 22 kD protein, which is named as heat shock protein22 (HSP22), is a member of sHSP (small heat shock protein) subfamily. It contains the α-crystallin domain in its C-terminal half, a hallmark of the subfamily of sHSP. HSP22 has Ser-Thr protein kinase activity and chaperone-like activity. HSP22 is expressed in multiple tissues, specially in skeletal muscle, placenta and heart. Previous studies showed that HSP22 involved in growth and transformation of cells, apoptosis of tumor, hypertrophy and apoptosis of myocardial cells. |
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| Keywords: | heat shock protein 22 small heat shock protein biological effect |
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