中性粒细胞胞外陷阱网在动脉粥样硬化进展中的作用

动脉粥样硬化是动脉血管壁长期渐进性的炎性病理过程。动脉粥样硬化斑块破裂及血栓形成所引起的急性心血管事件,严重威胁人类健康及生命。近年来中性粒细胞在动脉粥样硬化中的作用受到广泛关注。活化的中性粒细胞向胞外释放网状结构,即中性粒细胞胞外陷阱网。中性粒细胞胞外陷阱网在自身免疫疾病、急性肺损伤、深静脉血栓等疾病中具有致病作用。大量研究表明中性粒细胞胞外陷阱网与动脉粥样硬化及血栓形成相关,其标志物可以作为冠心病的预测因子,预测心脏主要不良事件及疾病预后。本文将就中性粒细胞胞外陷阱网在动脉粥样硬化进展中的作用进行综述。

Neutrophil extracellular traps have a role in the development of atherosclerosis

Atherosclerosis, which takes place in the walls of arteries, is a long-term progressive inflammatory pathological process. The rupture of atherosclerotic plaque and thus thrombosis may lead to acute cardiovascular events which threaten human health and life seriously. Recently, the role of neutrophils in atherosclerosis is attractted much attention.Activated neutrophils release web-like structures known as neutrophil extracellular traps (NETs). NETs affect the pathologic process in the patients with autoimmune diseases, acute lung injury, deep vein thrombosis, etc. A large number of studies indicate that NETs is associated with the formation of atherosclerosis and thrombosis. NETs, which act as predictive factors in coronary artery diseases, predict the major adverse cardiac events and the prognosis. This article is aimed to review the role of neutrophil extracellular traps in the development of atherosclerosis.