T cells recognize antigen alone and not MHC molecules |
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| Affiliation: | 1. Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior MCMBB, Philipps-University of Marburg, Marburg, Germany;2. Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany;3. Institute of Human Genetics, Department of Genetic Epidemiology, University Hospital Münster, Münster, Germany;4. Cardiology II-Electrophysiology, University Hospital Münster, Münster, Germany;5. National Heart and Lung Institute, Imperial College London, London, United Kingdom;6. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom;7. Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy;8. Cardiovascular Center, University of Ferrara, Ferrara and Maria Cecilia Hospital, GVM Care & Research, Cotignola (RA), Italy;9. Policlinico S. Matteo, Pavia, Italy;10. Dubowitz Neuromuscular Centre, Developmental Neuroscience Programme, University College of London, Institute of Child Health, London, United Kingdom;11. Department of Cardiology, University Hospital Birmingham, Birmingham, United Kingdom |
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| Abstract: | ![]()
It is a central dogma of contemporary immunology that T cells engaged in immune responses to foreign antigens or cells recognize determinants on major histocompatibility complex (MHC) molecules. Here Ole Werdelin argues that this dogma is false. Taking the case of T-cell responses which are controlled by MHC class II molecules, he suggests that la molecules serve to bind antigen fragments and stabilize them in the membrane of presenting cells, shielding them from proteolytic degradation and permitting T cells to bind the epitopes so displayed. |
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