阻塞性睡眠呼吸暂停低通气综合征患者糖、脂代谢紊乱的研究

目的通过观察OSAHS患者血清内脂素、血糖、甘油三酯水平的变化，探讨糖脂代谢紊乱与0sAHS的相关性。方法选择OsAHS患者45例，轻度OSAHS患者组20例，中重度0sAHS患者组25例。选择正常对照组20例。采取酶联免疫吸附法（ELISA）测定空腹血清内脂素的浓度，常规检测血糖、甘油三酯。结果轻度及中重度OSAHS组与正常对照组比较，血清内脂素水平均升高（F=38．59，P〈0．01）；中重度OsAHS组与轻度OSAHS组比较，血清内脂素水平升高（t=2．93，P〈0．01）。轻度OSAHS组与正常对照组比较，甘油三酯水平升高（t=2．97，P〈0．01）。血糖升高不明显（t=1．58，P〉O．05）；中重度0sAHS组与正常对照组比较，甘油三酯、血糖水平均升高（t=4．26，3．01，P值均〈0．01）。中重度0sAHs组与轻度0sAHS组比较，甘油三酯、血糖水平升高（t=3．12，2．93，P值均〈O．01）。血清内脂素与反映睡眠呼吸严重程度的指标有相关性（r=0．83，0．615，0．715，0．642，0．710，P值均〈O．01）。结论0sAHS患者存在血清内脂素、血糖、甘油三酯水平的异常，且与OSAHS的病情严重程度相关，说明0SAHS与糖脂代谢紊乱具有相关性。

Study of disorder of the serum glucose and glycolipid metabolism in patients with obstructive sleep apneahypopnea syndrome

Objective To investigate the changes of the serum visfatin, glucose and triglyceride levels in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS）. To explore the disorder of the glucose and triglyceride metabolism in patients with OSAHS. Methods Forty-five males with OSAHS were included randomly in the study,all patients with OSAHS were divided into two groups： mild OSAHS patients, moderate and severe OSAHS patients, of which 20 patients with mild OSAHS, 25 patients with moderate and severe OSAHS. There were 20 healthy control subjects. The Serum visfatin, glucose and triglyceride concentrations were measured by ELISA. Results Serum visfatin was higher in patients with mild OSAHS,moderate and severe OSAHS than control subjects （ F =38.59, P 〈0.01）. Serum triglyceride was higher in patients with mild OSAHS than those in control subjects （ t = 2.97, P 〈0.01）,serum glucose has not statistical significances （t = 1.58, P 〈 0.05）. Serum glucose and triglyceride were higher in patients with moderate and severe OSAHS than those with mild OSAHS （ t = 3.12,2.93,all P 〈0.01）. The serum visfatin levels were correlated positively with AHI in patients with OSAHS （ r = 0.83, P d0.01）, were correlated positively with serum triglyceride （ r --0. 589, P 〈0.01）, were correlated positively with serum glucose （ r = 0. 512, P 〈 0.01 ）, were correlated positively with SaO2 %90 % （ r = 0.615, P 〈 0.01 ）, were correlated positively with percentage of sleep time the total duration of apnea/hypopnea （r = 0. 715, P 〈 0.01）, were correlated positively with longest duration of apnea/hypopnea （ r = 0. 316, P 〈 O. 05）, were correlated negatively with the lowest SaO2 （ r = -0. 642, P 〈0.01） ,were correlated negatively with the average lowest SaO2 （ r = --0. 710, P〈0.01）. Conclusions These results suggest that the serum visafatin, glucose and triglyceride levels were ahnormality in patients with （-）SAILS, and were correlated positively with the severity, that shows the disorder of the glucose and glycolipid metabolism in patients with OSAHS.