黏蛋白MUC5AC与肺部疾病的研究进展

黏蛋白是由气道上皮杯状细胞和黏膜下层的黏液细胞分泌的一种高相对分子质量糖蛋白。MUC5AC作为气道黏液中最为重要的黏蛋白，起保护和润滑上皮作用，可防御外来具有生物活性的刺激物质，阻止细菌在气道植入和生长，参与上皮生长、更新和分化，细胞识别和信号传导等。众多研究表明，MUC5AC与肺部疾病如支气管哮喘、COPD、弥漫性泛细支气管炎、支气管扩张、肺癌、肺囊性纤维化等有着密切的关系。随着对其研究的深入，MUC5AC将有望成为新药作用的靶点，在肺部疾病的治疗方面发挥着重要作用。本文就MUC5AC的种类、结构、信号传导通路与肺部疾病的关系进行综述。

Research progress of MUC5AC in lung disease

Mucins are high-molecular-weight glycoproteins secreted by airway epithelial goblet cells and submucosal mucous cells. As the most important airway mucin protein, MUCSAC can prevent the growth and implantation of bacteria in the airway, participate in the epithelial growth, renewal and differentiation, cell recognition and signal transduction. Many studies show that MUC5AC has great correlation with lung diseases such as asthma, chronic obstructive pulmonary disease, diffuse panbronchiolitis,bronchieetasis, lung cancer, and cystic fibrosis. With the deeper research, MUCSAC is expected to become a new drug target, plays an important role in the treatment of lung diseases. This article reviews the types, structure, signal transduction pathway of MUCSAC and the relationship of it with lung diseases.