耐甲氧西林金黄色葡萄球菌生物膜及其致病性与防治研究进展

耐甲氧西林金黄色葡萄球菌（methicillin—resistant Staphylococcus aureus，MRSA）感染的流行使其成为医院和社区获得性感染的重要致病菌，MRSA具有传播速度快、流行范围广、多部位感染、多耐药性特点，与乙型肝炎、艾滋病并称当今世界三大感染顽疾。而MRSA生物膜的形成使感染慢性化并普难以控制，为临床防治带来极大困难。本文对MRSA生物膜的形成过程、群体感应系统、致病性及耐药机制、防治策略进行综述。充分认识和理解其发生发展规律、治疗策略及临床重要性具有十分重要的意义。

Research progress on infection and treatment of methiciUin-resistant Staphylococcus aureus biofilm

The prevalence of methicillin-resistant Staphylococcus aureus （MRSA） infection makes it as an important pathogen for hospital-and community-acquired infections. MRSA spreads fast and widely with multi-site infection and multi-drug resistance. MRSA, hepatitis B and AIDS are called the three leading refractory infections in the world nowadays. The formation of MRSA biofilm makes the infection to be chronic and difficult to control and brings great difficulties for clinical treatment. The formation process of MRSA biofilm, the quorum sensing system, pathogenicity and resistance mechanisms of MRSA,and control strategies are discussed in the article. It is of great significance to fully understand the evolution nature, the therapeutie strategies and be alert of its increasing clinical importance.