探讨抗精子抗体检验对男性不育症的应用价值

目的评价抗精子抗体检验对男性不育症的应用价值。方法病例选自2012年1月至2013年8月来我院就诊的390例不育症患者，收集所有患者的精液并对精子密度、精子活动百分率、精子活动力、精液中白细胞数量、精液量及精液液化时间进行分析．利用酶联免疫吸附试验检测血清抗精子抗体（Asab）。结果390例患者中，精子密度在0．24亿／mL以上的患者共302倒，其中抗精子抗体阳性患者52例，占17．2％；精子密度在0．2亿／mL以下的患者共88例，其中抗精子抗体阳性患者61例，占69．3％，经比较，差异有统计学意义（P〈0．05）。精子密度越高的患者，血清中抗精子抗体阳性率越低（P〈0．05），死精与无精患者血清中抗精子抗体阳性率高达75．6％、70％；精子活动力越差，血清中抗精子抗体检出率越高（P〈0．05），精液中白细胞计数越高，抗精子抗体阳性率越高（P〈0．05）。结论抗精子抗体检验在男性不育症的诊断中有较好的临床价值，值得在临床上推广。

Application Value of the Anti-Sperm Antibody Test in Male Infertility

Objective To evaluate application value of the anti-sperm antibodies in the treatment of male infertility test application. Methods 390 cases of infertile patients in our hospital from January 2012 to August 2013 were as research object. Their sperm concentration, sperm motility percentage sperm motility, the number of leukocytes in semen, semen volume and semen liquefaction time were analyzed, and serum anti-sperm antibodies （Asab） were detected with enzyme-linked immunosorbent assay. Results Among the 390 patients, 302 cases are with sperm density of 20 million/mL, including 52 cases （accounting for 17.2%） with positive anti-sperm antibodies; 88 cases are with sperm density less than 20 million/mL, including 61 cases （accounting for 69.3%） with positive anti-sperm antibodies. The difference is statistically significant （P〈0.05）. The higher the density of sperm is, the lower the serum anti-sperm antibody positive rate is （P〈0.05）. Serum anti-sperm antibody positive rate of patients with dead sperm and azoospermia is as high as 75.6% and 70%. As sperm motility is poorer, serum anti-sperm antibody detection rate is higher （P〈0.05）; as more white blood cell in semen, the rate of anti-sperm antibodies is higher （P〈0.05）. Conclusions Anti-sperm antibody test is effective in the diagnosis of male infertility, and it is worthy of promotion in clinical practice.