| 不同多孔PLGA／纳米羟基磷灰石复合支架加载辛伐他汀药物释放性能的研究 |
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| 引用本文： | 胡飞,周磊,周东风,吴王喜.不同多孔PLGA／纳米羟基磷灰石复合支架加载辛伐他汀药物释放性能的研究[J].医疗保健器具,2013(12):1480-1481. |
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| 作者姓名： | 胡飞 周磊 周东风 吴王喜 |
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| 作者单位： | 广东省口腔医院,广东广州510280 |
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| 基金项目： | 基金项目：广东省自然科学基金（9151008901000028） |
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| 摘 要： | 目的研究不同多孔PLGA／纳米羟基磷灰石复合支架加载辛伐他汀的药物释放性能。方法采用PLGA颗粒和纳米羟基磷灰石颗粒为原料，制备五种加载辛伐他汀的复合支架材料，并用分光光度仪测定每种复合支架材料辛伐他汀释放情况。结果加载辛伐他汀的五种类型复合支架，体外药物释放均呈缓慢持续性释放达到60d以上，60天累积释放率达70～90％，其中采用产气颗粒沥析技术的两种支架材料释放速度较为均衡。结论加载辛伐他汀的多孔PLGA／纳米羟基磷灰石复合支架具有良好的药物释放性能。
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| 关 键 词： | 多孔PLGA 辛伐他汀 羟基磷灰石 |
Study on Dissolution Rates of Different Simvastatin Loaded Porous PLGA/Nano Hydroxyapatite Composite Scaffold Materials |
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| HU Fei,ZHOU Lei,ZHOU Dongfeng,WU Wangxi.Study on Dissolution Rates of Different Simvastatin Loaded Porous PLGA/Nano Hydroxyapatite Composite Scaffold Materials[J].Medicine Healthcare Apparatus,2013(12):1480-1481. |
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| Authors: | HU Fei ZHOU Lei ZHOU Dongfeng WU Wangxi |
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| Institution: | (Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China |
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| Abstract: | Objective To study the dissolution rates of different simvastatin loaded porous PLGA/nano hydroxyapatite composite scaffold materials. Methods PLGA particles and nano HA particles were used to make different simvastatin loaded porous PLGA/nano hydroxyapatite. The dissolution rates of simvastatin were studied. Results Five materials had a dramatic slow releasing efficiency more than 60 days. Among them, the materials made of gas-produced Particulate leaching technology got better releasing efficiency. Conclusions The simvastatin loaded by Porous PLGA/nano hydroxyapatite composite scaffold material has good releasing efficiency. |
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| Keywords: | Porous PLGA Simvastatin Hydroxyapatite |
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