脐血白细胞介素8因子与生后2年婴幼儿反复喘息的相关性研究

目的探讨脐血细胞因子与生后二年内婴儿反复喘息的相关性。方法抽取200例正常出生的足月新生儿脐血,排除生后出现呼吸窘迫综合症及病理性黄疸的新生儿标本8例,剩余192例脐血检测IL-2、IL-4、IL-6、IL-8、IL-10、IL-1p、IL-12、IL-17水平;新生儿通过电话或者门诊追踪随访观察二年,随访到172例,其中反复喘息婴儿（喘息次数大于等于2次）30例。将上述172例婴儿分为喘息组（30例）及对照组（142例）,两组脐血细胞因子水平比较采用独立样本的r检验进行统计学分析。结果喘息组与非喘息组比较,IL-8有明显升高,差异有显著性（P〈0．05）。而IL-2、IL-4、IL-6、IL-10、IL—1β、IL-12、IL-17细胞因子水平喘息组与非喘息组比较,差异无显著性（P〉0．05）。结论IL-8可成为生后二年婴幼儿反复喘息的预测因子。

Association between cord blood cytokine and the development of wheezy infants in the first year of life.

Objective： To investigate the association between cord blood cytokine and the development of wheezy infants at age 2 years. Methods： Cord blood serum samples from 200 children were collected and stored. 8 cases were excluded for neonatal respiratory difficulties or pathologic jaundice. 192 cases were assayed for IL - 2 , IL-4, IL-6, IL-8, IL-10, IL-1β, IL-12, IL-17. 172 cases were followed - up for at least 2 year to monitor the development of wheezing illness by telephone interview or clinical service. Children with wheezing illness were 30 cases, and the control group without wheezing illness were 142. Results： The expressions of IL - 8 were （22. 2286 ± 7. 2046） pg/mL in wheezing group and （ 18. 8552 ± 7. 6587） pg/mL in control group, respectively, which had significant difference （p = 0. 032）. There were no significant difference in the expressions of IL- 2, IL- 4, IL- 6, IL- 10, IL - 1β, IL - 12, IL - 17 between two groups （P 〉 0. 05 ）. Conclusions ： IL - 8 may be a predictor for recurrent wheezing at age 2 years.